Scientific Program

 

Program by Day

 

 

 

Saturday, April 1, 2017

6:30 – 7:30 pm







Opening Keynote Session 

Welcome Remarks
Stewart Cole, Heran Darwin, 
and Bill Jacobs

If We Had a Better Drug or Vaccine, Would We Control TB?
Barry Bloom; 
Harvard T.H. Chan School of Public Health, Boston, MA  

Pathway to Care: Lessons for Defining a TB Strategy at the Gates Foundation
Gilla Kaplan; Bill and Melinda Gates Foundation, Seattle, WA

7:30 – 9:00 pm          Welcome Reception


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Sunday, April 2, 2017
 

9:00 am – 12:30 pm
  
Session 1: Physiology of Mycobacteria I
Chair: Jessica Seeliger
9:00 – 9:30 am

 

The Cell Wall of Mycobacterium Tuberculosis and 
New Drug Discovery Against Tuberculosis; a 50-year Odyssey
Patrick Brennan; 
Colorado State University, Fort Collins, CO  
9:30 – 9:50 am


Mycobacterium Tuberculosis Integration Host Factor:
Characterization of an Essential Nucleoid Associated Protein”
Nina T. Odermatt; EPFL, Switzerland
9:50 – 10:10 am


A Protein Nα-Acetyltransferase of Mycobacterium Tuberculosis
Alka Rao;
CSIR-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, India
10:10 – 10:30 am


Rv3723 Coordinates Fatty Acid and Cholesterol Utilization in
Mycobacterium Tuberculosis
Brian VanderVen; Cornell University, Ithaca, NY
10:30 – 11:00 am Coffee Break
11:00 – 11:30 am

The Space Between: Interrogating the Mycobacterium Cell Envelope
Jessica Seeliger
; Stony Brook University School of Medicine, Stony Brook, NY  
11:30 am – 11:50 am


Intracellular Mycobacterium Tuberculosis Requires Two Gateways into
Gluconeogenesis and Multiple CO2 Fixation Routes
Dany J. Beste; University of Surrey, Guildford, UK
11:50 – 12:10 pm

Exploiting the Aspartate Pathway to Kill Mycobacterium Tuberculosis
Michael Berney; Albert Einstein College of Medicine, Bronx, NY
12:10 – 12:30 pm


Characterization of the Type VII Secretion Membrane Complex
and the Role of Mycosin
Wilbert Bitter; VU Med. Centre, Amsterdam, Netherlands
12:30 – 2:00 pm

Lunch and Meet the PO 
Roundtable with NIAID Program Officers
Alison Kraigsley and André McBride

2:00 – 5:30 pm

Session 2: Systems Analysis of Mycobacteria
Chair: Stewart Cole
2:00 – 2:30 pm

Systems Approach to the ESX-1 Secretion System
Stewart Cole; 
École Polytechnique Fedérale de Lausanne, Lausanne, Switzerland
2:30 – 2:50 pm

Repression of the ESX-1 Secretion System - Mechanisms,
Consequences and Implications
Jeff Chen; VIDO-InterVac, University of Saskatchewan, Saskatoon, SK, Canada
2:50 – 3:10 pm


Regulation of ESX-5 Secretion and Membrane Vesicle Production
by the Phosphate Sensing Pst-SenX3-RegX3 System
Anna D. Tischler; University of Minnesota, Minneapolis, MN
3:10 – 3:30 pm

MTB Transcriptional Responses that Interfere with Survival
in a Mouse Infection
Tige Rustad; Center for Infectious Disease Research, Seattle, WA
3:30 – 4:00 pm Coffee Break
4:00 – 4:30 pm

Links Between Mycobacterial RNA Metabolism and Antibiotic Susceptibility
Scarlett Shell;
 Worcester Polytechnic Institute, Worcester, MA
4:30 – 4:50 pm


SOS-Dependent Mutasome Recruitment and Griselimycin-Mediated
Inhibition of Mutagenesis in Live Mycobacterial Cells
Michael Reiche; University of Cape Town, Observatory, South Africa
4:50 – 5:10 pm

Novel Insights into M. Tuberculosis Stress Responses
Adel Talaat; University of Wisconsin-Madison, Madison, WI
5:10 – 5:30 pm


Combined Host-Pathogen Profiling Reveals Links Between
Known and Novel Mycobacterium Tuberculosis Virulence Genes
Amy Barczak; Massachusetts General Hospital, Cambridge, MA
5:30 – 7:00 pm Poster Session A 


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Monday, April 3, 2017

 

9:00 am – 12:30 pm

Session 3: Location, Structure, Location 
Chair: Georgiana Purdy
9:00 – 9:30 am

The Function and Regulation of Mtb Mmpl Transporters
Georgiana Purdy; 
Oregon Health Sciences University, Portland, OR   
9:30 – 9:50 am


Investigation of the Spatio-Temporal Dynamics of Peptidoglycan
Synthesis in Mycobacterium Tuberculosis
Julien Vaubourgeix; Weill Medical College of Cornell University, New York, NY
9:50 – 10:10 am


Exploiting Reporter Strains to Unravel Mycobacterium Tuberculosis
Environmental Response and Infection Heterogeneity
Shumin Tan; Tufts Medical School, Boston, MA
10:10 – 10:30 am


A Phenotyping Toolkit for Studying Mycobacterial
Physiology at the Single-cell Level
Neeraj DHAR, EPFL, Switzerland
10:30 – 11:00 am Coffee Break
11:00 – 11:30 am

 

Emergence of the Tuberculosis Agent – 
From the Mycobacterium Canetti Pool to Mycobacterium Tuberculosis
Roland Brosch;
 Institut Pasteur, Paris, France
11:30 – 11:50 am


A Dramatic Increase in Hydrophobicity is Pivotal
in the Evolution of Pathogenic Tubercle Bacilli
David Minnikin; The University of Birmingham, Birmingham, UK
11:50 am – 12:10 pm


Exploitation of a Novel Mycobacterium Tuberculosis
Cidal Toxin for the Development of New Medicines Against Tuberculosis
Olivier Neyrolles; CNRS-University of Toulouse, Toulouse, France
12:10 – 12:30 pm


Lipid Composition of Lipid Droplets in
Mycobacterium Tuberculosis-Infected Macrophages
Valentina Guerrini; Public Health Research Insitute, Newark, NJ
12:30 – 2:00 pm Lunch
2:00 – 5:30 pm Session 4: At the Host-Pathogen Interface
Chair: Miriam Braunstein
2:00 – 2:30 pm

 

The Role of the SecA2 Pathway in 
Secreting Phagosome Maturation Arrest Factors
Miriam Braunstein; 
University of North Carolina, Chapel Hill, NC
2:30 – 2:50 pm


Engaging the CD40-CD40L Pathway Augments Th17
Responses and Protective Immunity to TB
Jyothi Rengarajan; Emory University, Atlanta, GA
2:50 – 3:10 pm


Inhibition of Neutrophil Necrosis Controls M. Tuberculosis
Growth After Removal by Macrophages
Tobias Dallenga; Research Center Borstel, Borstel, Germany
3:10 – 3:30 pm


Mycobacterium Tuberculosis and the Macrophage;
from Disease Progression to Drug Development
Yossef Av-Gay; University of British Columbia, Vancouver, BC, Canada
3:30 – 4:00 pm Coffee Break
4:00 – 4:30 pm

 

Transcriptomic Approaches Reveal the Human Immune
Response in Tuberculosis:
Strategies to Improve Mouse Models of Human Disease
Anne O'Garra; Francis Crick Institute, London, UK

4:30 – 4:50 pm


Evaluating Peripheral Blood Noncoding Small RNAs as
Biomarkers for Latent and Active Mycobacterium Tuberculosis Infection
Leondardo de Araujo; Fiocruz, Rio de Janeiro, Brazil
4:50 – 5:10 pm

Role of the Transcription Factor Ipr1 in Mediating Resistance to TB in Mice
Daisy Ji; University of California, Berkeley, Berkeley, CA
5:10 – 5:30 pm




Transcriptional and Translational Profiling: Insights
into Genome Architecture and Reannotation of the M. Smegmatis
and M. Tuberculosis Genomes
Keith Derbyshire;
Wadsworth Center, New York State Department of Health, Albany, NY
5:30 – 7:00 pm Poster Session B


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Tuesday, April 4, 2017

9:00 am – 1:00 pm

Session 5: Physiology of Mycobacteria II    
Chair: Heran Darwin 
9:00 – 9:30 am

Non–Canonical Nitrogen Metabolism in Mycobacterium Tuberculosis
Luiz Pedro Carvalho
; Francis Crick Institute, London, UK
9:30 – 9:50 am


Targeting Mycobacterium Tuberculosis DosRST Signaling and Persistence
Robert Abramovitch; Michigan State University, East Lansing, MI
9:50 – 10:10 am


Alternative Ribosomes Assembled in Zinc-Starved
Mycobacteria Decrease Sensitivity to Antibiotics
Anil Ojha; Wadsworth Center, NYSDOH, Albany, NY
10:10 – 10:30 am



Tackling the Functional Contribution of the
TNF Pathway and CFTR in Innate Immunity to
Mycobacterium Abscessus Infection
Laurent Kremer; CNRS FRE3689, Montpellier, France
10:30 – 11:00 am Coffee Break
11:00 – 11:30 am

Hot (News) Flash: Hormone Signaling in M. Tuberculosis
Heran Darwin
; New York University School of Medicine, NY, NY      
11:30 – 11:50 am




Elimination of Persistent Mycobacterium Tuberculosis
by Targeting Resuscitation Promoting Factor
(RPF)-dependent Bacteria -
New Tactics Against an Old Foe
Yanmin Hu; Inst. for Infection and Immunity, London, UK
11:50 am – 12:10 pm


The Trojan Horse: How Macrophage Exposure
Induces Antibiotic-Refractory Persisters
Suzie Hingley-Wilson; University of Surrey, Guildford, UK

12:10 – 1:00 pm

 

‘Unknown unknowns’ – What Surprises Does TB Have Left?
Clif E. Barry, III; National Institutes of Health, Bethesda, MD
and
TB Eradication: What We Need to Get There
William R. Jacobs, Jr.
; Albert Einstein College of Medicine/
Howard Hughes Medical Institute, NY, NY

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